Ubiquinone vs. Ubiquinol: Which Type of CoQ10 is Better?

What’s the difference between ubiquinol and ubiquinone?

Both ubiquinol and ubiquinone are true forms of CoQ10, and the terms are often used interchangeably. From a chemistry standpoint, ubiquinol is the reduced form of CoQ10, whereas ubiquinone is the oxidized form.

Ubiquinol and ubiquinone: is one better than the other?

Research has not proven one form of CoQ10 better than the other, and given the body naturally converts between the two forms, it is unlikely that there is a big difference between them.

Which form of CoQ10 is more bioavailable?

The bioavailability of a supplement is the proportion which reaches systemic circulation and can be used by the body. Both ubiquinone and ubiquinol have high bioavailability.

CoQ10 for fertility

Female fertility


  • CoQ10 is a natural antioxidant, and both forms of CoQ10 — ubiquinol and ubiquinone — are considered safe with few side effects.
  • More clinical trials have been conducted with ubiquinone than ubiquinol.
  • Ubiquinone and ubiquinol shift from one form to the other inside the body.
  • In terms of absorption and bioavailability, there is no clear cut difference between ubiquinone and ubiquinol.
  • Ubiquinol is trademarked, patented, and produced by one private company, and costs more to manufacture than ubiquinone.
  • Any supplement routine should be discussed with your physician who can give further guidance on what is best for you.



Get the Medium app

A button that says 'Download on the App Store', and if clicked it will lead you to the iOS App store
A button that says 'Get it on, Google Play', and if clicked it will lead you to the Google Play store


Fertility and pregnancy products. Inspired by beauty and backed by science. By moms, for you. ✨ www.natalist.com