The Role of CoQ10 in Fertility

Since we know CoQ10 is so integral to energy stored in all cells, it makes sense that supplementation could potentially help women with lower ovarian reserve to improve mitochondrial activity and energy production in the ovaries.

Much of the research in this area is still ongoing. Several studies have been conducted both in mice and human women. The studies in mice have shown that old mice given CoQ10 have improved outcomes more similar to young mice — meaning they have higher egg counts, more eggs ovulated after ovarian stimulation, and embryos had less chromosomal abnormalities.

  • For example, one study from 2016 took patients who were poor responders in their previous IVF cycle and had half of them supplement with CoQ10 for 12 weeks while the other group did not supplement. No significant improvement in outcome (number of eggs retrieved) was found between the two groups. There were only 78 total patients in this study, however, which wasn’t enough subjects to detect a true difference.
  • On the other hand, a study combined CoQ10 supplementation with clomiphene citrate (an ovulation induction agent) in PCOS patients who were resistant to clomiphene citrate alone. In these patients, the addition of CoQ10 did improve ovulation as well as clinical pregnancy rates (37% vs 6%).
  • A recent study in 2018 found that pretreating young women who had poor ovarian reserve with CoQ10 prior to an IVF cycle improved ovarian response to stimulation. The clinical pregnancy and live birth rates per embryo transfer and per stimulation cycle were also noted to be higher in the CoQ10 group, but again, were not statistically significant because of the small study size.

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